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What is Cloxacillin?

  • Cloxacillin is an antibiotic which is effective in treating certain bacteria.

How is Cloxacillin prescribed?

  • Your doctor will describe how he or she would like you to use Cloxacillin..  You should take it on an empty stomach.  Do not take with fruit juice or carbonated drinks.
  • For children older than 1 year the dose is according to weight
  • It is important to take Cloxacillin for the full period it is prescribed.  Take it for the full period (unless you feel unwell, in which case you should stop)

Can I use Cloxacillin with other treatments? 

  • It is sometimes recommended that those on an oral contraceptive use a back-up method of protection while on Cloxacillin

Tell your physician if you are on these medications:

  • Antacids
  • Beta-blockers
  • Blood thinning drugs
  • Chloramphenicol
  • Erythromycin
  • NSAIDs like Aleve or ibuprofen
  • Oral contraceptives
  • Probenecid
  • Tetracycline, doxycycline, minocycline,
  • methotrexate, cholostyramine,
  • allopurinol

Drugs other than those listed above may also interact with cloxacillin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines

Who should not use Cloxacillin?

  • DO not take Cloxacillin if you are allergic to Cloxacillin or Penicillin or  Cephalosporin type antibiotics. 
  • Tell your physician if you have ever had asthma, colitis, diabetes, or kidney or liver disease before taking Cloxacillin.
  • All women must inform  their physicians and health care team if they are pregnant or breast feeding before using Cloxacillin.
  • Before taking this medication, tell your doctor if you have kidney disease, stomach or intestinal disease, or infectious mononucleosis. You may not be able to take cloxacillin because of an increased risk of side effects.

What side effects are possible with Cloxacillin?

  • Upset stomach, diarrhea, nausea, vomiting, anxiety, colitis, confusion, convulsions, dizziness, hives, liver problems and jaundice, fungal infections, rash,
  • Tooth discoloration in children
  • Appetite loss.
  • White patches on the tongue (thrush/yeast infection);
  • Itching or discharge of the vagina (vaginal yeast infection); or
  • Black, "hairy" tongue or sore mouth or tongue.
  • Side effects other than those listed here may also occur. Be sure to let your doctor know  about any side effect that seems unusual or that is especially bothersome.
  • Rare irritation of liver (hepatitis)
  • Rare drop in blood counts (with long term users)
  • Rare infectious diarrhea called pseudomembranous colitis

What side effects should prompt me to STOP Cloxacillin?

  • Stop taking Cloxacillin if you experience reactions such as rash, fever, itching, joint pain, swollen lymph nodes, and or sores on the genitals and get medical attention right away
  • Stop taking Cloxacillin if an allergic reaction develops (shortness of breath; closing of your throat; hives; swelling of your lips, face, or tongue; rash; or fainting);  get medical attention right away
  • Stop taking Cloxacillin if you get seizures and get medical attention right away
  • Stop taking Cloxacillin if you develop severe watery diarrhea and abdominal cramps and get medical attention right away
  • Stop taking Cloxacillin if you develop unusual bleeding or bruising and get medical attention  

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